Phenotypes associated with this allele

• Allele Symbol: Meis2^tm1.2Zkoz
• Allele Name: targeted mutation 1.2, Zbynek Kozmik
• Allele ID: MGI:5911948
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Meis2^tm1.2Zkoz/Meis2^tm1.2Zkoz	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J	MGI:5911949

Genotype
MGI:5911949

hm1

• Allelic Composition: Meis2^tm1.2Zkoz/Meis2^tm1.2Zkoz
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:229604 )

• die between E13.5 and E14.5

cardiovascular system

persistent truncus arteriosus ( J:229604 )

• incomplete septation at E12.5

absent heart valves ( J:229604 )

• absent aortic and pulmonary valves at E13

hemorrhage ( J:229604 )

• extensive

hematopoietic system

anemia ( J:229604 )

• in embryos, probably as a result of extensive hemorrhage

embryo

increased embryonic tissue cell apoptosis ( J:229604 )

• primarily in the liver

embryonic growth retardation ( J:229604 )

• appear to stop growing at E13.5

liver/biliary system

increased hepatocyte apoptosis ( J:229604 )

• in embryos

abnormal liver morphology ( J:229604 )

• large regions with disrupted cellular organization and absence of erythrocytes in embryos

small liver ( J:229604 )

• in embryos

nervous system

absent trigeminal ganglion ( J:229604 )

• small or absent at E10

small trigeminal ganglion ( J:229604 )

• small or absent at E10

abnormal facial nerve morphology ( J:229604 )

• severely impaired and abnormally positioned at E10.5

abnormal trigeminal nerve morphology ( J:229604 )

• severely impaired and abnormally positioned at E10.5

abnormal vestibulocochlear nerve morphology ( J:229604 )

• severely impaired and abnormally positioned at E10.5

vision/eye

abnormal cornea morphology ( J:229604 )

• not developed properly at E13.5

abnormal eyelid morphology ( J:229604 )

• not developed properly at E13.5

cellular

increased embryonic tissue cell apoptosis ( J:229604 )

• primarily in the liver

increased hepatocyte apoptosis ( J:229604 )

• in embryos

growth/size/body

embryonic growth retardation ( J:229604 )

• appear to stop growing at E13.5

decreased fetal size ( J:229604 )

• at E14.5