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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mettl3tm1Jhha
targeted mutation 1, Jacob Hanna
MGI:5911703
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mettl3tm1Jhha/Mettl3tm1Jhha involves: 129S4/SvJae * C57BL/6 MGI:5911732


Genotype
MGI:5911732
hm1
Allelic
Composition		 Mettl3tm1Jhha/Mettl3tm1Jhha
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettl3tm1Jhha mutation (0 available); any Mettl3 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:219587 )
• despite being present at E3.5, all mice are resorbed by E8.5

embryo
abnormal embryo development ( J:219587 )
• deformed embryos at E5.5 to E7.5
• however, embryos are normal at E3.5
abnormal egg cylinder morphology ( J:219587 )
• deficient in adopting the epiblast egg cylinder




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory