Analysis Tools
mortality/aging
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• mice die at 18-26 days after birth
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• mice die at 18-26 days after birth
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Allele Symbol Allele Name Allele ID |
Tg(Myh6-Tnni3*R146G)121Rbns transgene insertion 121, Jeffrey Robbins MGI:5909328 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die at 18-26 days after birth
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• mice die at 18-26 days after birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some cardiomyocytes from parous females show features of hypoxia as evidenced by swollen mitochondria and large gaps between the sarcoplasmic reticulum, mitochondria, and sarcomeres
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• 13 month postpartum females exhibit cardiomyocyte hypertrophy
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• 13 month postpartum females exhibit patchy areas of interstitial and perivascular fibrosis
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• heart contractility is enhanced
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• heart relaxation is impaired, with the time constant of relaxation prolonged
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• skinned papillary muscle from 6 week old mice show increased calcium sensitivity and depressed maximum tension
• however, no differences are seen in unloaded shortening velocity, maximum shortening velocity, or maximum relative power
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• females stressed by pregnancy develop cardiac pathology
• however, males and nulliparous females exhibit no discernible heart pathology at any age
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• females stressed by pregnancy develop cardiac pathology
• however, males and nulliparous females exhibit no discernible heart pathology at any age
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• some cardiomyocytes from parous females show features of hypoxia as evidenced by swollen mitochondria and large gaps between the sarcoplasmic reticulum, mitochondria, and sarcomeres
|
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• heart contractility is enhanced
|
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• heart relaxation is impaired, with the time constant of relaxation prolonged
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• 13 month postpartum females exhibit cardiomyocyte hypertrophy
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• 13 month postpartum females exhibit patchy areas of interstitial and perivascular fibrosis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hypertrophic cardiomyopathy 7 | DOID:0110313 |
OMIM:613690 |
J:243628 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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