All Phenotypes Mcm3<tm1.2Geno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mcm3^tm1.2Geno
targeted mutation 1.2, Genoway
MGI:5907492

Summary

2 genotypes

Allelic Composition	Mcm3^tm1.2Geno/Mcm3^tm1.2Geno
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3^tm1.2Geno mutation (0 available); any Mcm3 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

Allelic Composition	Mcm3^tm1.2Geno/Mcm3⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3^tm1.2Geno mutation (0 available); any Mcm3 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:227638 )

• slight but significant reduction in lifespan

neoplasm

increased metastatic potential ( J:227638 )

• increased invasiveness of lymphomas

increased tumor incidence ( J:227638 )

• mainly lymphomas originating in the mesenteric lymph nodes that in multiple cases infiltrate to other organs

increased lymphoma incidence ( J:227638 )

• earlier onset and increased invasiveness

decreased tumor latency ( J:227638 )

• of lymphomas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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