Phenotypes associated with this allele

• Allele Symbol: Mlip^{tm1.1(cre)Dzw}
• Allele Name: targeted mutation 1.1, Da-Zhi Wang
• Allele ID: MGI:5907348
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlip^tm1.1(cre)Dzw/Mlip^tm1.1(cre)Dzw	involves: C57BL/6	MGI:5907350
cx2	Lmna^tm1Stw/Lmna^+ Mlip^tm1.1(cre)Dzw/Mlip^tm1.1(cre)Dzw	involves: 129S1/Sv * C57BL/6	MGI:5907352
cx3	Lmna^tm1Stw/Lmna^tm1Stw Mlip^tm1.1(cre)Dzw/Mlip^tm1.1(cre)Dzw	involves: 129S1/Sv * C57BL/6	MGI:5907353
cx4	Lmna^tm1Stw/Lmna^tm1Stw Mlip^tm1.1(cre)Dzw/Mlip^+	involves: 129S1/Sv * C57BL/6	MGI:5907354
cx5	Mlip^tm1.1(cre)Dzw/Mlip^tm1.1(cre)Dzw Tg(Myh6-Ppp3ca)37Eno/0	involves: C57BL/6 * FVB	MGI:5907351

Genotype
MGI:5907350

hm1

• Allelic Composition: Mlip^{tm1.1(cre)Dzw}/Mlip^{tm1.1(cre)Dzw}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:227485 )

• greater increase in cross-sectional area following transverse aortic constriction compared to controls

increased heart left ventricle weight ( J:227485 )

• increase in absolute and relative left ventricular mass at 11 months of age but not in mice at 3 or 6 months of age

dilated heart left ventricle ( J:227485 )

• increase in left ventricular dimension in aged mice

• transverse aortic constriction induced dramatic left ventricular dilation unlike in wild-type controls where this treatment induces left ventricular hypertrophy

cardiac fibrosis ( J:227485 )

• extensive fibrosis following transverse aortic constriction

abnormal cardiovascular system physiology ( J:227485 )

• depressed cardiac function in older mice

• however, no detectable cardiac defects in young mice

decreased cardiac muscle contractility ( J:227485 )

• decrease in ejection fraction and fractional shortening at 11 and 18 months of age but not at 3 or 6 months of age

• dramatic decrease following transverse aortic constriction

abnormal response of heart to induced stress ( J:227485 )

• transverse aortic constriction induced dramatic left ventricular dilation unlike in wild-type controls where this treatment induces left ventricular hypertrophy

increased response of heart to induced stress ( J:227485 )

• dramatic decrease in cardiac contraction and increase in fibrosis and cardiomyocyte size following transverse aortic constriction

homeostasis/metabolism

abnormal response of heart to induced stress ( J:227485 )

• transverse aortic constriction induced dramatic left ventricular dilation unlike in wild-type controls where this treatment induces left ventricular hypertrophy

increased response of heart to induced stress ( J:227485 )

• dramatic decrease in cardiac contraction and increase in fibrosis and cardiomyocyte size following transverse aortic constriction

muscle

increased myocardial fiber size ( J:227485 )

• greater increase in cross-sectional area following transverse aortic constriction compared to controls

decreased cardiac muscle contractility ( J:227485 )

• decrease in ejection fraction and fractional shortening at 11 and 18 months of age but not at 3 or 6 months of age

• dramatic decrease following transverse aortic constriction

Genotype
MGI:5907352

cx2

• Allelic Composition: Lmna^tm1Stw/Lmna⁺; Mlip^{tm1.1(cre)Dzw}/Mlip^{tm1.1(cre)Dzw}
• Genetic Background: involves: 129S1/Sv * C57BL/6

cardiovascular system

dilated heart left ventricle ( J:227485 )

• progressive increase in left ventricular internal dimension at end-diastole from 6 to 12 months of age

dilated cardiomyopathy ( J:227485 )

• at 12 months of age

decreased cardiac muscle contractility ( J:227485 )

• progressive decrease in fractional shortening from 6 to 12 months of age

muscle

dilated cardiomyopathy ( J:227485 )

• at 12 months of age

decreased cardiac muscle contractility ( J:227485 )

• progressive decrease in fractional shortening from 6 to 12 months of age

Genotype
MGI:5907353

cx3

• Allelic Composition: Lmna^tm1Stw/Lmna^tm1Stw; Mlip^{tm1.1(cre)Dzw}/Mlip^{tm1.1(cre)Dzw}
• Genetic Background: involves: 129S1/Sv * C57BL/6

mortality/aging

premature death ( J:227485 )

• die earlier than mice homozygous for the Lmna mutation alone

cardiovascular system

dilated heart left ventricle ( J:227485 )

• dilation is more severe than in mice homozygous for the Lmna mutation alone

decreased cardiac muscle contractility ( J:227485 )

• cardiac dysfunction is more severe than in mice homozygous for the Lmna mutation alone

muscle

decreased cardiac muscle contractility ( J:227485 )

• cardiac dysfunction is more severe than in mice homozygous for the Lmna mutation alone

Genotype
MGI:5907354

cx4

• Allelic Composition: Lmna^tm1Stw/Lmna^tm1Stw; Mlip^{tm1.1(cre)Dzw}/Mlip⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

mortality/aging

premature death ( J:227485 )

• die earlier than mice homozygous for the Lmna mutation alone

Genotype
MGI:5907351

cx5

• Allelic Composition: Mlip^{tm1.1(cre)Dzw}/Mlip^{tm1.1(cre)Dzw}; Tg(Myh6-Ppp3ca)37Eno/0
• Genetic Background: involves: C57BL/6 * FVB

mortality/aging

premature death ( J:227485 )

• half die by 10 weeks of age and all die by 18 weeks of age

• die earlier than mice carrying Tg(Myh6-Ppp3ca)37Eno alone

• appear to die from heart failure

cardiovascular system

decreased heart left ventricle wall thickness ( J:227485 )

• decrease in left ventricular wall thickness

dilated heart left ventricle ( J:227485 )

• increase in left ventricular dimension and decrease in wall thickness

decreased cardiac muscle contractility ( J:227485 )

• fractional shortening is around 10%

muscle

decreased cardiac muscle contractility ( J:227485 )

• fractional shortening is around 10%