Phenotypes associated with this allele

• Allele Symbol: Mirc6^tm1.1Mzhu
• Allele Name: targeted mutation 1.1, Min-Sheng Zhu
• Allele ID: MGI:5907298
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc6^tm1.1Mzhu/Mirc6^tm1.1Mzhu	B6.129(Cg)-Mirc6^tm1.1Mzhu	MGI:5907301
ht2	Mirc6^tm1.1Mzhu/Mirc6^+	B6.129(Cg)-Mirc6^tm1.1Mzhu	MGI:5907308

Genotype
MGI:5907301

hm1

• Allelic Composition: Mirc6^tm1.1Mzhu/Mirc6^tm1.1Mzhu
• Genetic Background: B6.129(Cg)-Mirc6^tm1.1Mzhu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:227271 )

• viable with no gross abnormalities

Genotype
MGI:5907308

ht2

• Allelic Composition: Mirc6^tm1.1Mzhu/Mirc6⁺
• Genetic Background: B6.129(Cg)-Mirc6^tm1.1Mzhu

muscle

abnormal muscle fiber morphology ( J:227271 )

• increase in type IIB fibers in the gastrocnemius muscle of mice with maternally inherited mutant allele

• type IIB fibers in the gastrocnemius muscle of mice with maternally inherited mutant allele are enriched in large fibers unlike wild-type mice

skeletal muscle hypertrophy ( J:227271 )

• fast-twitch muscle hypertrophy is seen in the gastrocnemius, tibialis anterior, and gluteus maximus muscles at P10 but not in mice over 3 weeks of age with a maternally inherited mutant allele

• however, the soleus muscle (slow-twitch muscle) is slightly smaller in neonatal mice with a maternally inherited mutant allele

• muscle mass is similar to wild-type controls in mice with a paternally inherited mutant allele

cellular

paternal imprinting ( J:227271 )

• the paternal allele is functionally inactivated