All Phenotypes Cdk12<tm1.2Mjfn> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdk12^tm1.2Mjfn
targeted mutation 1.2, Ming-Ji Fann
MGI:5906608

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk12^tm1.2Mjfn/Cdk12^tm1.2Mjfn	involves: FVB/N	MGI:5906659
cn2	Cdk12^tm1.1Mjfn/Cdk12^tm1.2Mjfn Sox2^tm1Rlb/Sox2⁺	involves: 129S/SvEv * FVB/N	MGI:5906660

Allelic Composition	Cdk12^tm1.2Mjfn/Cdk12^tm1.2Mjfn
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk12^tm1.2Mjfn mutation (0 available); any Cdk12 mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:242195 )

• no mice are present at E6.5

• however, mice are present at E3.5

embryo

abnormal inner cell mass morphology ( J:242195 )

• impaired expansion and increased apoptosis of the blastocyst at 3 and 4 days in vitro

abnormal trophoblast giant cell morphology ( J:242195 )

• failure to form a monolayer of trophoblast giant cells at 3 and 4 days in vitro

cellular

increased apoptosis ( J:242195 )

• increased apoptosis in the inner cell mass at 2 days in vitro

chromosomal instability ( J:242195 )

• increased double-strand breaks

Allelic Composition	Cdk12^tm1.1Mjfn/Cdk12^tm1.2Mjfn Sox2^tm1Rlb/Sox2⁺
Genetic Background	involves: 129S/SvEv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk12^tm1.1Mjfn mutation (0 available); any Cdk12 mutation (76 available)
Cdk12^tm1.2Mjfn mutation (0 available); any Cdk12 mutation (76 available)
Sox2^tm1Rlb mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:242195 )

• no mice are present at E6.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24