Phenotypes associated with this allele

• Allele Symbol: Hand2os1^em1Eno
• Allele Name: endonuclease-mediated mutation 1, Eric N Olson
• Allele ID: MGI:5906350
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hand2os1^em1Eno/Hand2os1^em1Eno	C57BL/6-Hand2os1^em1Eno	MGI:5906409
cx2	Hand1^tm1Eno/Hand1^+ Hand2os1^em1Eno/Hand2os1^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:5906410

Genotype
MGI:5906409

hm1

• Allelic Composition: Hand2os1^em1Eno/Hand2os1^em1Eno
• Genetic Background: C57BL/6-Hand2os1^em1Eno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:241318 )

cardiovascular system

cardiovascular system phenotype ( J:241318 )

N • unlike Hand2^tm1Dsr homozygotes, mice do not exhibit vascular defects in the aortic arch arteries and the aortic sac

common ventricle ( J:241318 )

• left-sided

absent heart right ventricle ( J:241318 )

pericardial effusion ( J:241318 )

embryo

embryonic growth retardation ( J:241318 )

• at E10.5

cellular

abnormal epigenetic regulation of gene expression ( J:241318 )

• reduced histone modifications (H3K4me1 and H3K27ac) in the heart

growth/size/body

embryonic growth retardation ( J:241318 )

• at E10.5

homeostasis/metabolism

pericardial effusion ( J:241318 )

Genotype
MGI:5906410

cx2

• Allelic Composition: Hand1^tm1Eno/Hand1⁺; Hand2os1^em1Eno/Hand2os1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

mortality/aging

embryonic lethality, complete penetrance ( J:241318 )

cardiovascular system

common ventricle ( J:241318 )

• left-sided

pericardial effusion ( J:241318 )

• at E11.5

growth/size/body

embryonic growth retardation ( J:241318 )

• at E11.5

embryo

embryonic growth retardation ( J:241318 )

• at E11.5

homeostasis/metabolism

pericardial effusion ( J:241318 )

• at E11.5