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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nop53tm1Asuz
targeted mutation 1, Akira Suzuki
MGI:5906161
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nop53tm1Asuz/Nop53tm1Asuz B6.129P2-Nop53tm1Asuz MGI:5906172
ht2
 		Nop53tm1Asuz/Nop53+ B6.129P2-Nop53tm1Asuz MGI:5906194


Genotype
MGI:5906172
hm1
Allelic
Composition		 Nop53tm1Asuz/Nop53tm1Asuz
Genetic
Background		 B6.129P2-Nop53tm1Asuz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nop53tm1Asuz mutation (0 available); any Nop53 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:241062 )
• morphologically normal up to E2.75
• no embryos formed proper blastocysts at E3.5 and all contained apoptotic cells




Genotype
MGI:5906194
ht2
Allelic
Composition		 Nop53tm1Asuz/Nop53+
Genetic
Background		 B6.129P2-Nop53tm1Asuz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nop53tm1Asuz mutation (0 available); any Nop53 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased papilloma incidence ( J:241062 )
• chemically induced skin papilloma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory