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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Primpolem1Nki
endonuclease-mediated mutation 1, The Netherlands Cancer Institute
MGI:5905761
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Primpolem1Nki/Primpolem1Nki C57BL/6-Primpolem1Nki MGI:5905775


Genotype
MGI:5905775
hm1
Allelic
Composition		 Primpolem1Nki/Primpolem1Nki
Genetic
Background		 C57BL/6-Primpolem1Nki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Primpolem1Nki mutation (0 available); any Primpol mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:242620 )
N
• mice exhibit normal T and B cell development and class switching
abnormal somatic hypermutation frequency ( J:242620 )
• B cells exhibit a selective increase in C to G transversions

hematopoietic system
abnormal somatic hypermutation frequency ( J:242620 )
• B cells exhibit a selective increase in C to G transversions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory