Phenotypes associated with this allele

• Allele Symbol: Syde1^tm1.1Hwch
• Allele Name: targeted mutation 1.1, Hungwen Chen
• Allele ID: MGI:5905625
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syde1^tm1.1Hwch/Syde1^tm1.1Hwch	involves: C57BL/6J	MGI:5905640

Genotype
MGI:5905640

hm1

• Allelic Composition: Syde1^tm1.1Hwch/Syde1^tm1.1Hwch
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

decreased embryo weight ( J:241798 )

• at E11.5 to E18.5

abnormal trophoblast giant cell morphology ( J:241798 )

• decreased invasion activity

abnormal spongiotrophoblast layer morphology ( J:241798 )

• cystic dysplasia at E14.5 and E18.5

abnormal placenta labyrinth morphology ( J:241798 )

• spongiotrophoblast dysplasia at E14.5

• increased vacuoles in layers I and II

abnormal placental labyrinth vasculature morphology ( J:241798 )

decreased placenta weight ( J:241798 )

• at E11.5 to E18.5

abnormal placenta development ( J:241798 )

• at E11.5 and E14.5, but less severe at E18.5

cardiovascular system

cardiovascular system phenotype ( J:241798 )

N • pregnant mice exhibit normal blood pressure

abnormal placental labyrinth vasculature morphology ( J:241798 )

increased vascular permeability ( J:241798 )

• between the placenta and yolk sac indicating compromised fetal and maternal blood circulation

cellular

increased apoptosis ( J:241798 )

• in the spongiotrophoblast layer at E18.5

growth/size/body

decreased embryo weight ( J:241798 )

• at E11.5 to E18.5