Phenotypes associated with this allele

• Allele Symbol: Sirt1^tm3.1Mcby
• Allele Name: targeted mutation 3.1,Michael W McBurney
• Allele ID: MGI:5903422
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sirt1^tm3.1Mcby/Sirt1^tm3.1Mcby	involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:5903485

Genotype
MGI:5903485

hm1

• Allelic Composition: Sirt1^tm3.1Mcby/Sirt1^tm3.1Mcby
• Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

short snout ( J:241633 )

• in tamoxifen treated mice

digestive/alimentary system

abnormal salivary gland morphology ( J:241633 )

• salivary gland contains lymphocyte infiltration in tamoxifen treate mice, but number of lymphocyte nests is fewer than in Sirt1^tm1Mcby homozygotes

endocrine/exocrine glands

abnormal salivary gland morphology ( J:241633 )

• salivary gland contains lymphocyte infiltration in tamoxifen treate mice, but number of lymphocyte nests is fewer than in Sirt1^tm1Mcby homozygotes

abnormal lacrimal gland morphology ( J:241633 )

• lacrimal gland contains lymphocyte infiltration in tamoxifen treated mice, but number of lymphocytes nests is fewer than in Sirt1^tm1Mcby homozygotes

growth/size/body

short snout ( J:241633 )

• in tamoxifen treated mice

reproductive system

reduced male fertility ( J:241633 )

♂ • untreated males have mildly reduced fertility

vision/eye

abnormal lacrimal gland morphology ( J:241633 )

• lacrimal gland contains lymphocyte infiltration in tamoxifen treated mice, but number of lymphocytes nests is fewer than in Sirt1^tm1Mcby homozygotes

ocular hypotelorism ( J:241633 )

• interorbital distance is reduced in tamoxifen treated mice