Phenotypes associated with this allele

• Allele Symbol: Cxcr5^tm1.1Namt
• Allele Name: targeted mutation 1.1, Neil A Mabbott
• Allele ID: MGI:5903012
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcr5^tm1.1Namt/Cxcr5^tm1.1Namt	involves: C57BL/6J	MGI:5903125
cn2	Cxcr5^tm1.1Namt/Cxcr5^tm1.1Namt Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:5903128
cn3	Cxcr5^tm1.1Namt/Cxcr5^tm1.1Namt Tg(Itgax-cre)1-1Reiz/0 Tg(Prnp)a20Cwe/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:5903129

Genotype
MGI:5903125

hm1

• Allelic Composition: Cxcr5^tm1.1Namt/Cxcr5^tm1.1Namt
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:241561 )

• mice are developmentally normal with normal lymphoid organogenesis and lymphoid structure, fertile with no observable phenotype

Genotype
MGI:5903128

cn2

• Allelic Composition: Cxcr5^tm1.1Namt/Cxcr5^tm1.1Namt; Tg(Itgax-cre)1-1Reiz/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

immune system

immune system phenotype ( J:241561 )

N • mice exhibit normal secondary lymphoid tissue formation

abnormal dendritic cell chemotaxis ( J:241561 )

• impaired chemotaxis toward CXCL13 in conventional dendritic cell

decreased follicular dendritic cell number ( J:241561 )

• marginal reduction in the follicle dendritic cells in the spleen

decreased susceptibility to prion infection ( J:241561 )

• following oral administration of scrapie prion proteins, mice exhibit reduced follicular dendritic cell-associated accumulation of prion protein in the spleen compared with control mice

• splenectomy before oral prion exposure does not alter susceptibility

• however, prion disease susceptibility is normal when infection is established directly within the CNS

cellular

abnormal dendritic cell chemotaxis ( J:241561 )

• impaired chemotaxis toward CXCL13 in conventional dendritic cell

hematopoietic system

abnormal dendritic cell chemotaxis ( J:241561 )

• impaired chemotaxis toward CXCL13 in conventional dendritic cell

Genotype
MGI:5903129

cn3

• Allelic Composition: Cxcr5^tm1.1Namt/Cxcr5^tm1.1Namt; Tg(Itgax-cre)1-1Reiz/0; Tg(Prnp)a20Cwe/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

immune system

decreased susceptibility to prion infection ( J:241561 )

• following oral administration of scrapie prion proteins, mice exhibit reduced follicular cell-associated prion infectivity in the spleen compared with control mice

• however, accumulation of prions in medial lymph nodes is normal