Phenotypes associated with this allele

• Allele Symbol: Igsf11^{tm1d(KOMP)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:5897622
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igsf11^tm1d(KOMP)Wtsi/Igsf11^tm1d(KOMP)Wtsi	involves: 129S4/SvJae * C57BL/6N	MGI:5897632

Genotype
MGI:5897632

hm1

• Allelic Composition: Igsf11^{tm1d(KOMP)Wtsi}/Igsf11^{tm1d(KOMP)Wtsi}
• Genetic Background: involves: 129S4/SvJae * C57BL/6N
• Cell Lines: EPD0297_2_A07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:234439 )

N • paired pulse ratio in perforant pathway dentate gyrus and SC-CA1 synapses

decreased excitatory postsynaptic current amplitude ( J:234439 )

• decreased miniature EPSCs in dentate gyrus granule cells

• however, frequency is normal and mEPSC amplitude and frequency in hippocampal CA1 pyramidal neurons is normal

reduced long-term potentiation ( J:234439 )

• in SC-CA1 synapses

• however, LTP is normal in medial perforant pathway dentate gyrus synapses