Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adatm1Mw mutation
(3 available);
any
Ada mutation
(30 available)
Adora2btm1Dgen mutation
(0 available);
any
Adora2b mutation
(19 available)
Tg(Afp-ADA)#Xiay mutation
(0 available)
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cardiovascular system
 N |
• preeclampsia features seen in Adatm1Mw/Adatm1Mw Tg(Afp-ADA)#Xiay/0 dams, including hypertension are ameliorated
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renal/urinary system
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N |
• preeclampsia features seen in Adatm1Mw/Adatm1Mw Tg(Afp-ADA)#Xiay/0 dams dams, including proteinuria and renal changes are ameliorated
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embryo
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• mice exhibit an increase in placental adenosine levels
• however, placental weight is increased and placental vasculature is more organized and uniform compared to Adatm1Mw/Adatm1Mw Tg(Afp-ADA)#Xiay/0 mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adatm1Mw mutation
(3 available);
any
Ada mutation
(30 available)
Tg(Afp-ADA)#Xiay mutation
(0 available)
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mortality/aging
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• mice die by 3 weeks of age because hepatic production of ADA subsides during the first week following birth
• however, treatment with adenosine deaminase enzyme replacement therapy prevents this lethality and the phenotypes described are with mice that have been treated with the replacement therapy from birth
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cellular
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• fetuses from mutant pregnant females are smaller and weigh less
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cardiovascular system
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• pregnant mice show impaired placental vasculature and reduced CD31+ vessels in the placenta
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• dams develop preeclampsia
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• dams show an increase in mean systolic blood pressure late in pregnancy beginning on E15.5, which remains elevated through E17.5 and returns to normal by day 5 postpartum
• mean arterial pressure is elevated on E18.5 in dams
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embryo
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• pregnant mice exhibit elevated placental adenosine levels at E12.5 that remain elevated through E18.5
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• pregnant mice show impaired placental vasculature and reduced CD31+ vessels in the placenta
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homeostasis/metabolism
renal/urinary system
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• urinary protein (ratio of albumin/creatinine) is elevated on E18.5 but not on E12.5, and this proteinuria is reduced to normal levels by postpartum day 7
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• swollen glomeruli with narrowed capillary and Bowmans spaces in pregnant mice
• pregnant mice show glomerular endotheliosis
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Analysis Tools