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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ddrgk1tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:5896836
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+ 		involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N MGI:5897612


Genotype
MGI:5897612
cn1
Allelic
Composition		 Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Cell Lines HEPD0618_2_D02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddrgk1tm1c(EUCOMM)Hmgu mutation (0 available); any Ddrgk1 mutation (20 available)
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:231701 )
• 3 weeks after tamoxifen treatment

hematopoietic system
abnormal embryonic erythropoiesis ( J:231701 )
• tamoxifen-treated mice exhibit impaired erythroid development at multiple stages
decreased erythrocyte cell number ( J:231701 )
• after tamoxifen treatment
decreased hemoglobin content ( J:231701 )
• after tamoxifen treatment
decreased granulocyte number ( J:231701 )
• after tamoxifen treatment
decreased lymphocyte cell number ( J:231701 )
• after tamoxifen treatment
decreased monocyte cell number ( J:231701 )
• after tamoxifen treatment
pancytopenia ( J:231701 )
• severe in adult mice treated with tamoxifen
abnormal hematopoietic stem cell physiology ( J:231701 )
• cell-autonomous impairment of hematopoietic stem cell function with activation of unfolded protein response and cell death after tamoxifen treatment

embryo
abnormal embryonic erythropoiesis ( J:231701 )
• tamoxifen-treated mice exhibit impaired erythroid development at multiple stages

growth/size/body
weight loss ( J:231701 )
• after tamoxifen treatment

immune system
decreased granulocyte number ( J:231701 )
• after tamoxifen treatment
decreased lymphocyte cell number ( J:231701 )
• after tamoxifen treatment
decreased monocyte cell number ( J:231701 )
• after tamoxifen treatment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory