Phenotypes associated with this allele

• Allele Symbol: Spop^{tm1c(KOMP)Mbp}
• Allele Name: targeted mutation 1c, Mouse Biology Program, UC Davis
• Allele ID: MGI:5896728
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gli3^Xt-J/Gli3^+ Spop^tm1c(KOMP)Mbp/Spop^tm1c(KOMP)Mbp Tg(Prrx1-cre)1Cjt/0	involves: C3H/HeJ * C57BL/6J * C57BL/6N * SJL/J	MGI:5896743
cn2	Spop^tm1c(KOMP)Mbp/Spop^tm1c(KOMP)Mbp Tg(Prrx1-cre)1Cjt/0	involves: C57BL/6J * C57BL/6N * SJL/J	MGI:5896741

Genotype
MGI:5896743

cn1

• Allelic Composition: Gli3^Xt-J/Gli3⁺; Spop^{tm1c(KOMP)Mbp}/Spop^{tm1c(KOMP)Mbp}; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J * C57BL/6N * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:239074 )

N • length of metacarpals, metatarsals and phalanges are similar to controls and significantly longer than in conditional mice wild-type for Gli3

N • near wild-type levels of bone density and thickness of bone spicules are restored in the femur

Genotype
MGI:5896741

cn2

• Allelic Composition: Spop^{tm1c(KOMP)Mbp}/Spop^{tm1c(KOMP)Mbp}; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * SJL/J

skeleton

abnormal femur morphology ( J:239074 )

• decreased density of the bone matrix in the primary and secondary ossification centers thinner bone spicules

• increase in specific bone surface and trabecular separation

decreased length of long bones ( J:239074 )

brachyphalangia ( J:239074 )

short metacarpal bones ( J:239074 )

short metatarsal bones ( J:239074 )

decreased bone mineral density ( J:239074 )

decreased bone volume ( J:239074 )

• decreased bone volume fraction in the femur

abnormal trabecular bone morphology ( J:239074 )

• increased trabecular separation in the femur

decreased bone trabecula number ( J:239074 )

• in the femur

decreased trabecular bone connectivity density ( J:239074 )

• in the femur

decreased trabecular bone thickness ( J:239074 )

• in the femur

decreased bone mass ( J:239074 )

decreased trabecular bone mass ( J:239074 )

• decrease in the trabecular bone density in the femur

abnormal bone ossification ( J:239074 )

limbs/digits/tail

brachyphalangia ( J:239074 )

brachydactyly ( J:239074 )

abnormal femur morphology ( J:239074 )

• decreased density of the bone matrix in the primary and secondary ossification centers thinner bone spicules

• increase in specific bone surface and trabecular separation

short metacarpal bones ( J:239074 )

short metatarsal bones ( J:239074 )