Phenotypes associated with this allele

• Allele Symbol: Anks1b^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5896631
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Anks1b^tm1b(KOMP)Wtsi/Anks1b^tm1b(KOMP)Wtsi	B6(FVB)-Anks1b^tm1b(KOMP)Wtsi	MGI:5906261

Genotype
MGI:5906261

hm1

• Allelic Composition: Anks1b^{tm1b(KOMP)Wtsi}/Anks1b^{tm1b(KOMP)Wtsi}
• Genetic Background: B6(FVB)-Anks1b^{tm1b(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:240601 )

• loss of pups between birth and weaning

nervous system

decreased prepulse inhibition ( J:240601 )

• significant PPI deficits using a 73 dB prepulse but not at higher prepulse intensities

behavior/neurological

enhanced behavioral response to xenobiotic ( J:240601 )

• enhanced sensitivity in males to ketamine's locomotor activating effects at lower doses (10 mg/kg) but similar responses at higher doses that decrease activity

increased locomotor activity ( J:240601 )

• increased activity levels in an open field

• enhanced sensitivity in males to ketamine's locomotor activating effects at lower doses (10 mg/kg) but similar responses at higher doses that decrease activity

increased stereotypic behavior ( J:240601 )

• elevated stereotypy count