Phenotypes associated with this allele

• Allele Symbol: Ntn1^tm1.2Good
• Allele Name: targeted mutation 1.2, Lisa Goodrich
• Allele ID: MGI:5888901
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntn1^tm1.2Good/Ntn1^tm1.2Good	involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL	MGI:7356224

Genotype
MGI:7356224

hm1

• Allelic Composition: Ntn1^tm1.2Good/Ntn1^tm1.2Good
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

coloboma ( J:277765 )

• at E15.5-E16.5, >90% of mice exhibit a bilateral ocular coloboma

• however, optic fissure margins are normally apposed at E11.5, when fusion is first initiated

craniofacial

abnormal palatal shelf fusion at midline ( J:277765 )

• at E15.5-E16.5, mice exhibit variably penetrant palate fusion defects

cleft secondary palate ( J:277765 )

• at E15.5-E16.5, ~36% of mice exhibit cleft secondary palate

digestive/alimentary system

abnormal palatal shelf fusion at midline ( J:277765 )

• at E15.5-E16.5, mice exhibit variably penetrant palate fusion defects

cleft secondary palate ( J:277765 )

• at E15.5-E16.5, ~36% of mice exhibit cleft secondary palate

growth/size/body

abnormal palatal shelf fusion at midline ( J:277765 )

• at E15.5-E16.5, mice exhibit variably penetrant palate fusion defects

cleft secondary palate ( J:277765 )

• at E15.5-E16.5, ~36% of mice exhibit cleft secondary palate