Phenotypes associated with this allele

• Allele Symbol: Tgfbi^tm1.1Nap
• Allele Name: targeted mutation 1.1, Nathalie Allaman-Pillet
• Allele ID: MGI:5888672
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgfbi^tm1.1Nap/Tgfbi^tm1.1Nap	B6N.129S(FVB)-Tgfbi^tm1.1Nap	MGI:5883589

Genotype
MGI:5883589

hm1

• Allelic Composition: Tgfbi^tm1.1Nap/Tgfbi^tm1.1Nap
• Genetic Background: B6N.129S(FVB)-Tgfbi^tm1.1Nap

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:230754 )

N • mice exhibit normal corneal development and show no apparent changes in retinal organization at P0 and P10

N • retinal angiogenesis appears unaffected

decreased retina apoptosis ( J:230754 )

• at P10, the number of apoptotic cells in the retinal inner nuclear layer (INL) is reduced relative to that in wild-type controls, leading to a transient increase in INL cell number at P15

• however, by P15, apoptosis is almost completely absent in the INL, as in wild-type retinas

abnormal retina inner nuclear layer thickness ( J:230754 )

• however, no difference is noted at the level of the outer nuclear layer (ONL)

• mice show a transient increase in retinal INL thickness at P15, no longer present at P30

• INL thickness is reduced by only 9% versus 40% in wild-type retina between P10 and P15

• cell nuclei number is increased by 25% in the INL at P15

• ERK activity is increased in the INL at P30, indicating upregulation of the ERK survival pathway

cellular

decreased retina apoptosis ( J:230754 )

• at P10, the number of apoptotic cells in the retinal inner nuclear layer (INL) is reduced relative to that in wild-type controls, leading to a transient increase in INL cell number at P15

• however, by P15, apoptosis is almost completely absent in the INL, as in wild-type retinas

neoplasm

neoplasm ( J:230754 )

N • mice are macroscopically normal and show no predisposition to spontaneous tumor development