Phenotypes associated with this allele

• Allele Symbol: Aggf1^tm1Qkw
• Allele Name: targeted mutation 1, Qing Kenneth Wang
• Allele ID: MGI:5882327
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aggf1^tm1Qkw/Aggf1^tm1Qkw	involves: 129 * C57BL/6	MGI:5882329
ht2	Aggf1^tm1Qkw/Aggf1^+	involves: 129 * C57BL/6	MGI:5882328

Genotype
MGI:5882329

hm1

• Allelic Composition: Aggf1^tm1Qkw/Aggf1^tm1Qkw
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:239252 )

• embryos die before E8.5

Genotype
MGI:5882328

ht2

• Allelic Composition: Aggf1^tm1Qkw/Aggf1⁺
• Genetic Background: involves: 129 * C57BL/6

embryo

abnormal vitelline vasculature morphology ( J:239252 )

• defective vascular development in yolk sacs

mortality/aging

embryonic lethality, incomplete penetrance ( J:239252 )

• fewer than the expected numbers of mice are recovered

cardiovascular system

abnormal vascular development ( J:239252 )

• defective vascular development in embryos and yolk sacs

abnormal tumor vascularization ( J:239252 )

• implanted melanoma cells that develop into tumors show decreased vascular density compared to controls

abnormal vitelline vasculature morphology ( J:239252 )

• defective vascular development in yolk sacs

internal hemorrhage ( J:239252 )

• about 35% of adult mice show hemorrhages in the brain, lungs, and other tissues

lung hemorrhage ( J:239252 )

abnormal vascular endothelial cell physiology ( J:239252 )

• microvascular endothelial cells (MECs) show decreased capability to form capillary tubes

increased vascular permeability ( J:239252 )

• adult mice show increased vascular permeability

neoplasm

abnormal tumor vascularization ( J:239252 )

• implanted melanoma cells that develop into tumors show decreased vascular density compared to controls

decreased tumor incidence ( J:239252 )

• tumor growth of both B16F10 and B16F0 melanoma cells is inhibited compared to growth in wild-type mice

respiratory system

lung hemorrhage ( J:239252 )