Phenotypes associated with this allele

• Allele Symbol: Muc4^tm1Skb
• Allele Name: targeted mutation 1, Surinder K Batra
• Allele ID: MGI:5829375
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Muc4^tm1Skb/Muc4^tm1Skb	involves: 129 * C57BL/6J	MGI:5829405

Genotype
MGI:5829405

hm1

• Allelic Composition: Muc4^tm1Skb/Muc4^tm1Skb
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to colitis induced morbidity/mortality ( J:234205 )

♂ • in DSS-treated male mice

digestive/alimentary system

decreased susceptibility to induced colitis ( J:234205 )

♂ • DSS-treated male mice exhibit increased survival with less severe colitis symptoms compared with wild-type mice

decreased susceptibility to colitis induced morbidity/mortality ( J:234205 )

♂ • in DSS-treated male mice

neoplasm

decreased incidence of tumors by chemical induction ( J:234205 )

• azoxymethane (AOM)/DSS-treated mice exhibit a 4-fold reduction in colorectal tumor nodules and less severe phenotype compared with wild-type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:234205 )

• azoxymethane (AOM)/DSS-treated mice exhibit a 4-fold reduction in colorectal tumor nodules and less severe phenotype compared with wild-type mice

immune system

decreased susceptibility to induced colitis ( J:234205 )

♂ • DSS-treated male mice exhibit increased survival with less severe colitis symptoms compared with wild-type mice

decreased susceptibility to colitis induced morbidity/mortality ( J:234205 )

♂ • in DSS-treated male mice