About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr39em1Ched
endonuclease-mediated mutation 1, Catherine Hedrick
MGI:5829195
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr39em1Ched/Rr39em1Ched C57BL/6-Rr39em1Ched MGI:5829816


Genotype
MGI:5829816
hm1
Allelic
Composition		 Rr39em1Ched/Rr39em1Ched
Genetic
Background		 C57BL/6-Rr39em1Ched
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr39em1Ched mutation (1 available); any Rr39 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased Ly6C low monocyte number ( J:239509 )
• substantial decrease in Ly6low peripheral blood monocytes

immune system
immune system phenotype ( J:239509 )
N
• response to high dose LPS challenge is similar to controls
decreased Ly6C low monocyte number ( J:239509 )
• substantial decrease in Ly6low peripheral blood monocytes

neoplasm
increased tumor growth/size ( J:239509 )
• following injection of B16F10 melanoma cells, mice exhibit a higher tumor burden than wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory