Phenotypes associated with this allele

• Allele Symbol: Setd7^tm1.1Ital
• Allele Name: targeted mutation 1.1, Iannis Talianidis
• Allele ID: MGI:5828599
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Setd7^tm1.1Ital/Setd7^tm1.1Ital	involves: C57BL/6 * CBA	MGI:5829229

Genotype
MGI:5829229

hm1

• Allelic Composition: Setd7^tm1.1Ital/Setd7^tm1.1Ital
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung morphology ( J:238299 )

♂ • mice exhibit a significant reduction in bleomycin- and adenovirus-TGFbeta-induced pulmonary fibrotic lesions relative to wild-type controls

♂ • however, no visible lung phenotypes are observed under normal conditions

abnormal lung compliance ( J:238299 )

♂ • following bleomycin or adenovirus-TGF-beta challenge, static compliance and dynamic compliance are decreased to a much lesser extent than in wild-type controls

homeostasis/metabolism

abnormal protein level ( J:238299 )

♂ • isolated primary lung fibroblasts show highly increased total Smad7 protein levels relative to wild-type cells

decreased physiological sensitivity to xenobiotic ( J:238299 )

♂ • mice exhibit a significant reduction in bleomycin-induced interstitial thickening, alveolar collapse, formation of cystic air spaces, and cross-linked collagen fiber deposition in the lungs relative to bleomycin-treated wild-type controls

decreased susceptibility to injury ( J:238299 )

♂ • mice exhibit a significant reduction in bleomycin- and adenovirus-TGFbeta-induced pulmonary fibrotic lesions relative to wild-type controls

cellular

abnormal extracellular matrix morphology ( J:238299 )

♂ • isolated primary lung fibroblasts show a significant decrease in TGF-beta-dependent activation of several genes encoding extracellular matrix (ECM) components relative to wild-type cells

♂ • following bleomycin or adenovirus-TGF-beta challenge, mice show a significant reduction in the activation of a large panel of ECM genes in the lungs relative to wild-type controls