Analysis Tools
nervous system
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• under resting conditions, adult brains exhibit normal cytoarchitecture with no alterations in neuronal distribution and density in the cerebral cortex and cerebellum and absence of astroglial activation in the hippocampus
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• 5-week-old mice show significantly decreased susceptibility to pilocarpine-induced seizures, as shown by a marked reduction in the % of mice undergoing status epilepticus, number of stage 5 tonic-clonic seizures, latency to the first stage 5 tonic-clonic seizure event, and pilocarpine-induced lethality over an 1.5 h observation period relative to age-matched wild-type controls
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• during the 1st hour after pilocarpine injection, 46% of mice show trains of spikes (tonic-clonic seizures: stage 4-5) versus 78% of wild-type controls
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• during the 1st hour after pilocarpine injection, 54% of mice show rhythmic spindle-like activity (absence, stage 1) versus 22% of wild-type controls
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• EEG analysis during the 1st h after pilocarpine injection revealed that 4-mo-old mice exhibit spindle-like events, unlike wild-type controls where trains of spikes are followed by voltage attenuation
• adult mice show lack of mean amplitude increase during the 2nd h after pilocarpine injection unlike wild-type controls
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behavior/neurological
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• 5-week-old mice show significantly decreased susceptibility to pilocarpine-induced seizures, as shown by a marked reduction in the % of mice undergoing status epilepticus, number of stage 5 tonic-clonic seizures, latency to the first stage 5 tonic-clonic seizure event, and pilocarpine-induced lethality over an 1.5 h observation period relative to age-matched wild-type controls
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• during the 1st hour after pilocarpine injection, 46% of mice show trains of spikes (tonic-clonic seizures: stage 4-5) versus 78% of wild-type controls
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• during the 1st hour after pilocarpine injection, 54% of mice show rhythmic spindle-like activity (absence, stage 1) versus 22% of wild-type controls
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mortality/aging
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• 5-week-old mice show decreased pilocarpine-induced lethality over an 1.5 h observation period relative to age-matched wild-type controls
• only 26% of adult mice die within 7 days after pilocarpine injection, in contrast to 78% of wild-type controls
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homeostasis/metabolism
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• only 26% of adult mice die within 7 days after pilocarpine injection, in contrast to 78% of wild-type controls
• 5-week-old mice show decreased pilocarpine-induced lethality over an 1.5 h observation period relative to age-matched wild-type controls
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