Phenotypes associated with this allele

• Allele Symbol: Zfy1^em2Asah
• Allele Name: endonuclease-mediated mutation 2, Hiroshi Asahara
• Allele ID: MGI:5824899
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Zfy1^em2Asah/Zfy1^em2Asah Zfy2^em2Asah/Zfy2^em2Asah	involves: C57BL/6 * DBA/2	MGI:8290602

Genotype
MGI:8290602

cx1

• Allelic Composition: Zfy1^em2Asah/Zfy1^em2Asah; Zfy2^em2Asah/Zfy2^em2Asah
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

asthenozoospermia ( J:238696 )

♂ • only 1% of sperm are motile

abnormal spermatogenesis ( J:238696 )

♂ • spermatogenesis is abnormal, however spermiogenesis in the testes is normal

abnormal outer dense fiber morphology ( J:238696 )

♂ • outer dense fibers are disrupted

abnormal sperm axoneme morphology ( J:238696 )

♂ • axonemes are disrupted

abnormal sperm mitochondrial morphology ( J:238696 )

♂ • sperm have abnormal mitochondria with abnormal mitochondria formation

hairpin sperm flagellum ( J:238696 )

♂

abnormal sperm head morphology ( J:238696 )

♂ • abnormal sperm heads are seen in the epididymis

abnormal acrosome morphology ( J:238696 )

♂

absent sperm head ( J:238696 )

♂ • acephalic sperm are seen in the epididymis

impaired sperm capacitation ( J:238696 )

♂

male infertility ( J:238696 )

♂ • no male mice produce any pups after mating with wild-type females

♂ • however, testes and epididymides are grossly normal, and testis and epididymal sperm count are normal

abnormal egg activation ( J:238696 )

♂ • intracytoplasmic sperm injection of wild-type oocytes results in premature chromosome condensation and failure to develop to the two-cell stage, indicating that sperm exhibit reduced oocyte activation

impaired fertilization ( J:238696 )

♂ • sperm fail to fertilize wild-type oocytes in in vitro fertilization

impaired acrosome reaction ( J:238696 )

♂

cellular

abnormal outer dense fiber morphology ( J:238696 )

♂ • outer dense fibers are disrupted

abnormal sperm axoneme morphology ( J:238696 )

♂ • axonemes are disrupted

abnormal sperm mitochondrial morphology ( J:238696 )

♂ • sperm have abnormal mitochondria with abnormal mitochondria formation

hairpin sperm flagellum ( J:238696 )

♂

abnormal sperm head morphology ( J:238696 )

♂ • abnormal sperm heads are seen in the epididymis

abnormal acrosome morphology ( J:238696 )

♂

absent sperm head ( J:238696 )

♂ • acephalic sperm are seen in the epididymis

asthenozoospermia ( J:238696 )

♂ • only 1% of sperm are motile