Phenotypes associated with this allele

• Allele Symbol: Zfy2^em1Asah
• Allele Name: endonuclease-mediated mutation 1, Hiroshi Asahara
• Allele ID: MGI:5824557
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfy2^em1Asah/Zfy2^em1Asah	involves: C57BL/6 * DBA/2	MGI:8290601

Genotype
MGI:8290601

hm1

• Allelic Composition: Zfy2^em1Asah/Zfy2^em1Asah
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal outer dense fiber morphology ( J:238696 )

♂ • outer dense fibers are disrupted

abnormal sperm axoneme morphology ( J:238696 )

♂ • axonemes are disrupted

abnormal sperm mitochondrial morphology ( J:238696 )

♂ • sperm exhibit abnormalities of mitochondrial formation

abnormal sperm head morphology ( J:238696 )

♂ • abnormal sperm heads are seen in the epididymis

abnormal acrosome morphology ( J:238696 )

♂

absent sperm head ( J:238696 )

♂ • acephalic sperm are seen in the epididymis

asthenozoospermia ( J:238696 )

♂ • number of motile sperm is reduced (70%) compared to wild-type (85.6%)

reduced male fertility ( J:238696 )

♂ • males are subfertile, with pregnancy success rates of 60% and deceased average litter size

♂ • and testis and epididymal sperm count are normal

cellular

abnormal outer dense fiber morphology ( J:238696 )

♂ • outer dense fibers are disrupted

abnormal sperm axoneme morphology ( J:238696 )

♂ • axonemes are disrupted

abnormal sperm mitochondrial morphology ( J:238696 )

♂ • sperm exhibit abnormalities of mitochondrial formation

abnormal sperm head morphology ( J:238696 )

♂ • abnormal sperm heads are seen in the epididymis

abnormal acrosome morphology ( J:238696 )

♂

absent sperm head ( J:238696 )

♂ • acephalic sperm are seen in the epididymis

asthenozoospermia ( J:238696 )

♂ • number of motile sperm is reduced (70%) compared to wild-type (85.6%)