Phenotypes associated with this allele

• Allele Symbol: F12^tm1Fjc
• Allele Name: targeted mutation 1, Francis J Castellino
• Allele ID: MGI:5824302
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F12^tm1Fjc/F12^tm1Fjc	involves: 129X1/SvJ * C57BL/6	MGI:5827979

Genotype
MGI:5827979

hm1

• Allelic Composition: F12^tm1Fjc/F12^tm1Fjc
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased partial thromboplastin time ( J:238837 )

• mice exhibit prolonged activated partial thromboplastin times

• however, prothrombin time of plasma is not different from wild-type plasma and no obvious unchallenged coagulopathies are present in adults

abnormal bradykinin level ( J:238837 )

• plasma levels of bradykinin are decreased

• bradykinin generation in plasma after contact activation is decreased

reproductive system

reproductive system phenotype ( J:238837 )

N • females exhibit normal pregnancies with normal litter sizes