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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Oprk1tm2.1Kff
targeted mutation 2.1, Brigitte L Kieffer
MGI:5823257
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Oprk1tm2.1Kff/Oprk1tm2.1Kff
Slc6a3tm1(cre)Xz/0 		involves: 129 * 129S1/Sv * C57BL/6 MGI:5824892
cn2
 		Oprk1tm2.1Kff/Oprk1tm2.1Kff
Tg(Fev-cre)1Esd/0 		involves: 129 * C57BL/6 * SJL MGI:5824893


Genotype
MGI:5824892
cn1
Allelic
Composition		 Oprk1tm2.1Kff/Oprk1tm2.1Kff
Slc6a3tm1(cre)Xz/0
Genetic
Background		 involves: 129 * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm2.1Kff mutation (1 available); any Oprk1 mutation (28 available)
Slc6a3tm1(cre)Xz mutation (2 available); any Slc6a3 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal associative learning ( J:226396 )
• resistant to agonist U50,488-induced conditioned place aversion (CPA)

nervous system
abnormal synaptic dopamine release ( J:226396 )
• evoked dopamine response is not inhibited, in contrast to inhibition of dopamine in controls




Genotype
MGI:5824893
cn2
Allelic
Composition		 Oprk1tm2.1Kff/Oprk1tm2.1Kff
Tg(Fev-cre)1Esd/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm2.1Kff mutation (1 available); any Oprk1 mutation (28 available)
Tg(Fev-cre)1Esd mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal associative learning ( J:226396 )
• resistant to agonist U50,488-induced conditioned place aversion (CPA), however, like controls, evoked dopamine response is inhibited in response to agonist




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory