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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tph2tm2.2Pasq
targeted mutation 2.2, Massimo Pasqualetti
MGI:5823173
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tph2tm2.2Pasq/Tph2tm2.2Pasq involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5823235
cn2
 		Tph2tm2.1Pasq/Tph2tm2.2Pasq
Tg(CMV-cre/ERT)1Ipc/0 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5823236


Genotype
MGI:5823235
hm1
Allelic
Composition		 Tph2tm2.2Pasq/Tph2tm2.2Pasq
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tph2tm2.2Pasq mutation (0 available); any Tph2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:238619 )
• some mice die within the first few days of birth

homeostasis/metabolism
decreased serotonin level ( J:238619 )
• undetectable in the rostral or caudal raphe nuclei

growth/size/body
decreased body weight ( J:238619 )
• in the first seven weeks after birth




Genotype
MGI:5823236
cn2
Allelic
Composition		 Tph2tm2.1Pasq/Tph2tm2.2Pasq
Tg(CMV-cre/ERT)1Ipc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-cre/ERT)1Ipc mutation (0 available)
Tph2tm2.1Pasq mutation (0 available); any Tph2 mutation (43 available)
Tph2tm2.2Pasq mutation (0 available); any Tph2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased serotonin level ( J:238619 )
• reduced in the brain of tamoxifen-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory