Phenotypes associated with this allele

• Allele Symbol: Pde10a^tm1.1Njbr
• Allele Name: targeted mutation 1.1, Nicholas J Brandon
• Allele ID: MGI:5823061
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pde10a^tm1.1Njbr/Pde10a^tm1.1Njbr	involves: C57BL/6	MGI:5823062

Genotype
MGI:5823062

hm1

• Allelic Composition: Pde10a^tm1.1Njbr/Pde10a^tm1.1Njbr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:231965 )

• mice show increases in forepaw bearing weight and decreases in hindpaw bearing weight indicating compensatory weight shifting from hindpaws to forepaws

impaired balance ( J:231965 )

• mice show a reduced ability to maintain their balance on an accelerating rotarod

impaired coordination ( J:231965 )

• mice show a reduced ability to maintain their balance on an accelerating rotarod

decreased vertical activity ( J:231965 )

• mice show less rearing behavior than controls

bradykinesia ( J:231965 )

• mice show less total distance traveled than controls