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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmprss6hem8
haematopoietic 8
MGI:5822806
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmprss6hem8/Tmprss6hem8 C57BL/6J-Tmprss6hem8 MGI:5829235
ht2
 		Tmprss6hem8/Tmprss6tm1Dgen involves: C57BL/6 * C57BL/6J MGI:5829240


Genotype
MGI:5829235
hm1
Allelic
Composition		 Tmprss6hem8/Tmprss6hem8
Genetic
Background		 C57BL/6J-Tmprss6hem8
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6hem8 mutation (0 available); any Tmprss6 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
alopecia ( J:237155 )
• body hair loss sparing the face at 2 months of age

hematopoietic system
hematopoietic system phenotype ( J:237155 )
N
• mice do not exhibit reticulocytosis
decreased mean corpuscular volume ( J:237155 )
• at 2 months of age

homeostasis/metabolism
increased circulating unsaturated transferrin level ( J:237155 )
• decreased transferrin saturations at 2 months of age
abnormal iron homeostasis ( J:237155 )
• increased liver hepcidin, Id1, and Tmprss6 RNA levels at 2 months of age
• however, liver Bmp6 RNA levels are normal
decreased circulating iron level ( J:237155 )
• decreased serum iron levels at 2 months of age
• however, spleen iron levels are normal
decreased liver iron level ( J:237155 )
• at 2 months of age

liver/biliary system
decreased liver iron level ( J:237155 )
• at 2 months of age




Genotype
MGI:5829240
ht2
Allelic
Composition		 Tmprss6hem8/Tmprss6tm1Dgen
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6hem8 mutation (0 available); any Tmprss6 mutation (44 available)
Tmprss6tm1Dgen mutation (0 available); any Tmprss6 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased mean corpuscular volume ( J:237155 )
• at 2 months of age
reticulocytosis ( J:237155 )
• increased reticulocyte counts at 2 months of age

homeostasis/metabolism
increased circulating unsaturated transferrin level ( J:237155 )
• decreased transferrin saturations at 2 months of age
abnormal iron homeostasis ( J:237155 )
• increased liver hepcidin RNA levels at 2 months of age
decreased circulating iron level ( J:237155 )
• decreased serum iron levels at 2 months of age
decreased liver iron level ( J:237155 )
• at 2 months of age

liver/biliary system
decreased liver iron level ( J:237155 )
• at 2 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory