Analysis Tools
liver/biliary system
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• mice exhibit no significant differences in the acute response to CCl4-induced liver injury and show normal liver regeneration after partial hepatectomy relative to similarly treated control mice
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• at 12 months of age, mice exhibit supernumerary, often dilated bile ducts that are still largely confined to the portal areas
• however, bile ducts show no apparent obstruction
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• at 2 and 12 months of age, mice show an increased number of bile duct epithelial cells (BECs), including periportal patches that represent KRT19-positive liver progenitor cells (LPCs)
• increased BEC proliferation index is confirmed by Ki-67 staining at 12 months of age
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• mice develop bile duct hyperplasia by 2 months of age
• ductular reaction is associated with biliary fibrosis at 2 and 12 months, as shown by collagen staining with Sirius Red; however, no hepatocellular injury or intrahepatic cholangiocarcinoma tumor development is observed over time
• mice fed a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC) for 3 weeks show enhanced bile duct hyperplasia relative to similarly treated controls, as determined by H&E, KRT19 and BrdU staining
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• mice exhibit supernumerary bile ducts at 12 months of age
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• bile ducts are often dilated at 12 months of age
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• mice show an increased number of F4/80-positive macrophages in the liver at 12 months of age
• however, leukocyte (CD45-positive) and activated hepatic stellate cell (alpha-SMA-positive) numbers remain normal
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• at 2 and 12 months of age, mice show an expansion of the periportal liver progenitor cell (LPC) compartment, as revealed by the KRT19-positive area
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• bile duct hyperplasia is associated with enhanced LPC proliferation
• after 3 weeks on a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC), mice exhibit a greater increase in chemically induced LPC proliferation relative to similarly treated controls, as determined by KRT19 and BrdU staining
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immune system
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• mice show an increased number of F4/80-positive macrophages in the liver at 12 months of age
• however, leukocyte (CD45-positive) and activated hepatic stellate cell (alpha-SMA-positive) numbers remain normal
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endocrine/exocrine glands
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• at 12 months of age, mice exhibit supernumerary, often dilated bile ducts that are still largely confined to the portal areas
• however, bile ducts show no apparent obstruction
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• at 2 and 12 months of age, mice show an increased number of bile duct epithelial cells (BECs), including periportal patches that represent KRT19-positive liver progenitor cells (LPCs)
• increased BEC proliferation index is confirmed by Ki-67 staining at 12 months of age
|
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• mice develop bile duct hyperplasia by 2 months of age
• ductular reaction is associated with biliary fibrosis at 2 and 12 months, as shown by collagen staining with Sirius Red; however, no hepatocellular injury or intrahepatic cholangiocarcinoma tumor development is observed over time
• mice fed a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC) for 3 weeks show enhanced bile duct hyperplasia relative to similarly treated controls, as determined by H&E, KRT19 and BrdU staining
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• mice exhibit supernumerary bile ducts at 12 months of age
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• bile ducts are often dilated at 12 months of age
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