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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tyrem8Ove
endonuclease-mediated mutation 8, Paul Overbeek
MGI:5818844
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tyrc/Tyrem8Ove involves: C57BL/6 * FVB MGI:5818865
cx2
 		A/?
Tyrem8Ove/Tyrem8Ove 		involves: C57BL/6 * FVB MGI:5818861


Genotype
MGI:5818865
ht1
Allelic
Composition		 Tyrc/Tyrem8Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc mutation (79 available); any Tyr mutation (382 available)
Tyrem8Ove mutation (1 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• the fur of these Tyr compound heterozygous mice is very light-colored

pigmentation
diluted coat color ( J:94077 )
• the fur of these Tyr compound heterozygous mice is very light-colored
decreased eye pigmentation ( J:94077 )
• the eyes of these mice are lightly pigmented

vision/eye
decreased eye pigmentation ( J:94077 )
• the eyes of these mice are lightly pigmented




Genotype
MGI:5818861
cx2
Allelic
Composition		 A/?
Tyrem8Ove/Tyrem8Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (80 available); any a mutation (468 available)
Tyrem8Ove mutation (1 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
decreased ear pigmentation ( J:94077 )
• the ears of mice homozygous for this Tyr promoter deletion on an agouti background appear gray
diluted coat color ( J:94077 )
• the fur of these mice appears light tan
decreased tail pigmentation ( J:94077 )
• tails of these mice exhibit minimal pigmentation

craniofacial
decreased ear pigmentation ( J:94077 )
• the ears of mice homozygous for this Tyr promoter deletion on an agouti background appear gray

limbs/digits/tail
decreased tail pigmentation ( J:94077 )
• tails of these mice exhibit minimal pigmentation

growth/size/body
decreased ear pigmentation ( J:94077 )
• the ears of mice homozygous for this Tyr promoter deletion on an agouti background appear gray

hearing/vestibular/ear
decreased ear pigmentation ( J:94077 )
• the ears of mice homozygous for this Tyr promoter deletion on an agouti background appear gray

pigmentation
decreased ear pigmentation ( J:94077 )
• the ears of mice homozygous for this Tyr promoter deletion on an agouti background appear gray
diluted coat color ( J:94077 )
• the fur of these mice appears light tan
decreased tail pigmentation ( J:94077 )
• tails of these mice exhibit minimal pigmentation

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory