All Phenotypes Il22ra1<tm1.1Koll> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il22ra1^tm1.1Koll
targeted mutation 1.1, Jay K Kolls
MGI:5817816

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺	involves: BALB/cJ * C57BL/6	MGI:6712738
cn2	Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll Riok2^{tm1c(KOMP)Wtsi}/Riok2⁺ Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: C57BL/6N * C57BL/10 * CBA/Ca	MGI:6712737

Allelic Composition	Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
Genetic Background	involves: BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (25 available)
Il22ra1^tm1.1Koll mutation (1 available); any Il22ra1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythroid progenitor cell number ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in RIII and RIV erythroid precursors in the bone marrow compared to controls

increased erythrocyte cell number ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in peripheral blood red blood cell numbers compared to controls

increased hematocrit ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in hematocrit compared to controls

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:305794 )

• mice show alleviation of stress-induced anemia, showing increased peripheral blood cell counts, increased hematocrit, and increase in erythroid precursors in the bone marrow following phenylhydrazine-induced stress erythropoiesis

Allelic Composition	Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll Riok2^{tm1c(KOMP)Wtsi}/Riok2⁺ Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: C57BL/6N * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Il22ra1^tm1.1Koll mutation (1 available); any Il22ra1 mutation (30 available)
Riok2^{tm1c(KOMP)Wtsi} mutation (0 available); any Riok2 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:305794 )

N	• mice show an improvement in peripheral blood red blood cell numbers and hematocrit levels, and an increase in RIII and RIV erythroid precursors in the bone marrow compared to Il22ra1-sufficient Riok2-haploinsufficent mice

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