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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tyrem6Ove
endonuclease-mediated mutation 6, Paul Overbeek
MGI:5817685
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tyrem6Ove/Tyrem6Ove involves: C57BL/6 * FVB MGI:5817689
cx2
 		A/?
Tyrc/Tyrem6Ove 		involves: C57BL/6 * FVB MGI:5817691


Genotype
MGI:5817689
hm1
Allelic
Composition		 Tyrem6Ove/Tyrem6Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrem6Ove mutation (1 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• on an agouti background, the fur of mice homozygous for this Tyr mutation appears light tan.

pigmentation
diluted coat color ( J:94077 )
• on an agouti background, the fur of mice homozygous for this Tyr mutation appears light tan.
variegated eye pigmentation pattern ( J:94077 )
• eyes are dark with mosaic pigmentation

vision/eye
variegated eye pigmentation pattern ( J:94077 )
• eyes are dark with mosaic pigmentation




Genotype
MGI:5817691
cx2
Allelic
Composition		 A/?
Tyrc/Tyrem6Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (80 available); any a mutation (468 available)
Tyrc mutation (79 available); any Tyr mutation (382 available)
Tyrem6Ove mutation (1 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• the fur of these Tyr compound heterozygous mice on an agouti background appears lighter tan than that of Tyrem6Ove homozygotes.

pigmentation
diluted coat color ( J:94077 )
• the fur of these Tyr compound heterozygous mice on an agouti background appears lighter tan than that of Tyrem6Ove homozygotes.
variegated eye pigmentation pattern ( J:94077 )
• eyes are dark with mosaic pigmentation

vision/eye
variegated eye pigmentation pattern ( J:94077 )
• eyes are dark with mosaic pigmentation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory