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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tyrem1Ove
endonuclease-mediated mutation 1, Paul Overbeek
MGI:5817494
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		A/?
Tyrem1Ove/Tyrem1Ove 		involves: C57BL/6 * FVB MGI:5817495
cx2
 		A/?
Tyrc/Tyrem1Ove 		involves: C57BL/6 * FVB MGI:5817496


Genotype
MGI:5817495
cx1
Allelic
Composition		 A/?
Tyrem1Ove/Tyrem1Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (80 available); any a mutation (468 available)
Tyrem1Ove mutation (1 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• mice homozygous for this endonuclease-mediated tyrosinase allele on an agouti background appear light agouti.

pigmentation
diluted coat color ( J:94077 )
• mice homozygous for this endonuclease-mediated tyrosinase allele on an agouti background appear light agouti.




Genotype
MGI:5817496
cx2
Allelic
Composition		 A/?
Tyrc/Tyrem1Ove
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (80 available); any a mutation (468 available)
Tyrc mutation (79 available); any Tyr mutation (382 available)
Tyrem1Ove mutation (1 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:94077 )
• mice with this compound heterozygous tyrosinase genotype on an agouti background appear light agouti.

pigmentation
diluted coat color ( J:94077 )
• mice with this compound heterozygous tyrosinase genotype on an agouti background appear light agouti.
decreased eye pigmentation ( J:94077 )
• these compound Tyr heterozygotes on an agouti background exhibit reduced eye pigmentation at birth.

vision/eye
decreased eye pigmentation ( J:94077 )
• these compound Tyr heterozygotes on an agouti background exhibit reduced eye pigmentation at birth.




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory