Phenotypes associated with this allele

• Allele Symbol: Smcr8^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5812680
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smcr8^tm1.1(KOMP)Vlcg/Smcr8^tm1.1(KOMP)Vlcg	involves: 129S1/SvImJ * C57BL/6J * C57BL/6NTac	MGI:5816930

Genotype
MGI:5816930

hm1

• Allelic Composition: Smcr8^{tm1.1(KOMP)Vlcg}/Smcr8^{tm1.1(KOMP)Vlcg}
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal autophagy ( J:236977 )

• phenotype of MEFs derived from E15.5 mutant embryos is stated to be identical to that of MEFs homozygous for the Smcr8^{tm1(KOMP)Vlcg} allele (via personal communication)

abnormal lysosome physiology ( J:236977 )

homeostasis/metabolism

abnormal autophagy ( J:236977 )

• phenotype of MEFs derived from E15.5 mutant embryos is stated to be identical to that of MEFs homozygous for the Smcr8^{tm1(KOMP)Vlcg} allele (via personal communication)

abnormal protein level ( J:236977 )