Phenotypes associated with this allele

• Allele Symbol: Pofut2^tm2.2Bch
• Allele Name: targeted mutation 2.2, Bernadette C Holdener
• Allele ID: MGI:5812116
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pofut2^tm2.2Bch/Pofut2^tm2.2Bch	B6.Cg-Pofut2^tm2.2Bch	MGI:5812910

Genotype
MGI:5812910

hm1

• Allelic Composition: Pofut2^tm2.2Bch/Pofut2^tm2.2Bch
• Genetic Background: B6.Cg-Pofut2^tm2.2Bch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo morphology ( J:234992 )

• at E7.5 embryos are shorter and rounder as compared to wild-type

• embryos appear constricted proximal to the epiblast

absent mesoderm ( J:234992 )

• E7.5 embryos lack mesoderm

disorganized embryonic tissue ( J:234992 )

• embryonic and extraembryonic epithelia are irregular

abnormal extraembryonic tissue morphology ( J:234992 )

• extraembryonic structures derived from mesoderm are absent

disorganized extraembryonic tissue ( J:234992 )

• embryonic and extraembryonic epithelia are irregular

abnormal visceral endoderm morphology ( J:234992 )

• visceral endoderm is thickened

abnormal anterior visceral endoderm morphology ( J:234992 )

• proximal visceral endoderm is polarized but lacks apical vacuoles

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:234992 )

• embryos are resorbed by E9.5