Analysis Tools|
Allele Symbol Allele Name Allele ID |
RhoTvrm334 translational research vision model 334 MGI:5810761 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• more rapid degeneration than in heterozygotes
|
|
• more rapid degeneration than in heterozygotes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the fundus appears grainy, and there is rapid photoreceptor degeneration and thinning of the retinal pigment epithelium, with a slightly thinned outer nuclear layer at 14 days of age and only 3 to 4 rows of photoreceptor nuclei at 21 days of age
• rhodopsin is mislocalized to the soma of photoreceptor cells
|
|
• the fundus appears grainy, and there is rapid photoreceptor degeneration and thinning of the retinal pigment epithelium, with a slightly thinned outer nuclear layer at 14 days of age and only 3 to 4 rows of photoreceptor nuclei at 21 days of age
• rhodopsin is mislocalized to the soma of photoreceptor cells
|
|
• although light adapted (cone) ERG readings are normal at 21 days of age, dark-adapted ERG shows severely diminished rod function
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| retinitis pigmentosa 4 | DOID:0110372 |
OMIM:613731 |
J:243745 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
