Phenotypes associated with this allele

• Allele Symbol: Pbrm1^tm1Zhwa
• Allele Name: targeted mutation 1, Zhong Wang
• Allele ID: MGI:5810066
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pbrm1^tm1Zhwa/Pbrm1^tm1Zhwa Tg(Cd4-cre)1Cwi/?	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5810068

Genotype
MGI:5810068

cn1

• Allelic Composition: Pbrm1^tm1Zhwa/Pbrm1^tm1Zhwa; Tg(Cd4-cre)1Cwi/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:236906 )

N

decreased T cell proliferation ( J:236906 )

• slight decrease in proliferative response following stimulation of CD4+ T cells

abnormal T-helper 2 cell differentiation ( J:236906 )

• number of IL10 producing Th2 cells is increased from 16% to 38%

• however, differentiation of Th1 and Th17 cells is similar to wild-type

increased interleukin-10 secretion ( J:236906 )

• increase in IL10 expression in naive CD4 T cells following stimulation with PMA and ionomycin

• number of IL10 producing Th2 cells is increased from 16% to 38%

increased interleukin-4 secretion ( J:236906 )

• slight increase in IL4 expression in naive CD4 T cells following stimulation with PMA and ionomycin

hematopoietic system

decreased T cell proliferation ( J:236906 )

• slight decrease in proliferative response following stimulation of CD4+ T cells

abnormal T-helper 2 cell differentiation ( J:236906 )

• number of IL10 producing Th2 cells is increased from 16% to 38%

• however, differentiation of Th1 and Th17 cells is similar to wild-type

cellular

decreased T cell proliferation ( J:236906 )

• slight decrease in proliferative response following stimulation of CD4+ T cells