About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zranb1tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:5806462
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zranb1tm1c(EUCOMM)Hmgu/Zranb1tm1c(EUCOMM)Hmgu
Tg(Cd4-cre)1Cwi/0 		involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2 MGI:5897846
cn2
 		Zranb1tm1c(EUCOMM)Hmgu/Zranb1tm1c(EUCOMM)Hmgu
Tg(Itgax-cre)1-1Reiz/0 		involves: 129S4/SvJaeSor * C57BL/6N * CBA MGI:5897848


Genotype
MGI:5897846
cn1
Allelic
Composition		 Zranb1tm1c(EUCOMM)Hmgu/Zranb1tm1c(EUCOMM)Hmgu
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (10 available)
Zranb1tm1c(EUCOMM)Hmgu mutation (0 available); any Zranb1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:235701 )
N
• mice treated with MOG(35-55) along with pertussis toxin exhibit normal EAE clinical scores




Genotype
MGI:5897848
cn2
Allelic
Composition		 Zranb1tm1c(EUCOMM)Hmgu/Zranb1tm1c(EUCOMM)Hmgu
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6N * CBA
Cell Lines HEPD0538_8_D07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Zranb1tm1c(EUCOMM)Hmgu mutation (0 available); any Zranb1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:235701 )
N
• mice exhibit normal dendritic cell development, migration and maturation
decreased T helper 1 cell number ( J:235701 )
• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin
decreased T-helper 17 cell number ( J:235701 )
• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin
abnormal dendritic cell physiology ( J:235701 )
• bone marrow-derived dendritic cells induce a 2- to 3-fold decrease in LPS-stimulated differentiation of CD4+ T cells into Th1 and Th17 cells
• however, induction of regulatory T cells is normal
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:235701 )
• mice treated with MOG(35-55) along with pertussis toxin exhibit delayed onset, decreased clinical score and reduced inflammation compared with wild-type mice

hematopoietic system
decreased T helper 1 cell number ( J:235701 )
• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin
decreased T-helper 17 cell number ( J:235701 )
• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory