Phenotypes associated with this allele

• Allele Symbol: Zranb1^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5806462
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Zranb1^tm1c(EUCOMM)Hmgu/Zranb1^tm1c(EUCOMM)Hmgu Tg(Cd4-cre)1Cwi/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2	MGI:5897846
cn2	Zranb1^tm1c(EUCOMM)Hmgu/Zranb1^tm1c(EUCOMM)Hmgu Tg(Itgax-cre)1-1Reiz/0	involves: 129S4/SvJaeSor * C57BL/6N * CBA	MGI:5897848

Genotype
MGI:5897846

cn1

• Allelic Composition: Zranb1^{tm1c(EUCOMM)Hmgu}/Zranb1^{tm1c(EUCOMM)Hmgu}; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:235701 )

N • mice treated with MOG(35-55) along with pertussis toxin exhibit normal EAE clinical scores

Genotype
MGI:5897848

cn2

• Allelic Composition: Zranb1^{tm1c(EUCOMM)Hmgu}/Zranb1^{tm1c(EUCOMM)Hmgu}; Tg(Itgax-cre)1-1Reiz/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * CBA
• Cell Lines: HEPD0538_8_D07

immune system

immune system phenotype ( J:235701 )

N • mice exhibit normal dendritic cell development, migration and maturation

decreased T helper 1 cell number ( J:235701 )

• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin

decreased T-helper 17 cell number ( J:235701 )

• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin

abnormal dendritic cell physiology ( J:235701 )

• bone marrow-derived dendritic cells induce a 2- to 3-fold decrease in LPS-stimulated differentiation of CD4+ T cells into Th1 and Th17 cells

• however, induction of regulatory T cells is normal

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:235701 )

• mice treated with MOG(35-55) along with pertussis toxin exhibit delayed onset, decreased clinical score and reduced inflammation compared with wild-type mice

hematopoietic system

decreased T helper 1 cell number ( J:235701 )

• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin

decreased T-helper 17 cell number ( J:235701 )

• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin