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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Leprm7Btlr
mutation 7, Bruce Beutler
MGI:5806340
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Leprm7Btlr/Leprm7Btlr C57BL/6J-Leprm7Btlr MGI:5807180


Genotype
MGI:5807180
hm1
Allelic
Composition		 Leprm7Btlr/Leprm7Btlr
Genetic
Background		 C57BL/6J-Leprm7Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprm7Btlr mutation (0 available); any Lepr mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgE level ( J:236685 )
• increased levels of IgE levels in the peripheral blood
decreased response to antigen ( J:236685 )
• increased levels of IgE levels in the peripheral blood

homeostasis/metabolism
increased circulating glucose level ( J:236685 )
• increased blood glucose levels 30 minutes after glucose bolus

cellular
decreased cell death ( J:236685 )
• reduced killing of natural killer target cells

hematopoietic system
increased IgE level ( J:236685 )
• increased levels of IgE levels in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory