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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd8am2Btlr
mutation 2, Bruce Beutler
MGI:5806327
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd8am2Btlr/Cd8am2Btlr C57BL/6J-Cd8am2Btlr MGI:5807128


Genotype
MGI:5807128
hm1
Allelic
Composition		 Cd8am2Btlr/Cd8am2Btlr
Genetic
Background		 C57BL/6J-Cd8am2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8am2Btlr mutation (0 available); any Cd8a mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased CD8-positive, alpha-beta memory T cell proliferation ( J:236677 )
• effector memory CD8+ T cells in CD8+ T cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:236677 )
• increase in the CD4+ to CD8+ T cell ratio caused by reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells, and increased and naive CD8+ T cells in CD8+ T cells

cellular
increased CD8-positive, alpha-beta memory T cell proliferation ( J:236677 )
• effector memory CD8+ T cells in CD8+ T cells

hematopoietic system
increased CD8-positive, alpha-beta memory T cell proliferation ( J:236677 )
• effector memory CD8+ T cells in CD8+ T cells
abnormal CD8-positive, alpha-beta T cell physiology ( J:236677 )
• increase in the CD4+ to CD8+ T cell ratio caused by reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells, and increased and naive CD8+ T cells in CD8+ T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory