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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irf9M1Btlr
mutation 1, Bruce Beutler
MGI:5806324
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irf9M1Btlr/Irf9M1Btlr C57BL/6J-Irf9M1Btlr MGI:5807119
ht2
 		Irf9M1Btlr/Irf9+ C57BL/6J-Irf9M1Btlr MGI:5807120


Genotype
MGI:5807119
hm1
Allelic
Composition		 Irf9M1Btlr/Irf9M1Btlr
Genetic
Background		 C57BL/6J-Irf9M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf9M1Btlr mutation (0 available); any Irf9 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cell death ( J:236674 )
• increased rate of macrophage necroptosis after treatment with lipolysaccharide

homeostasis/metabolism
increased circulating interferon-beta level ( J:236674 )
• slight increase in type I interferon production after dsDNA exposure

immune system
increased circulating interferon-beta level ( J:236674 )
• slight increase in type I interferon production after dsDNA exposure




Genotype
MGI:5807120
ht2
Allelic
Composition		 Irf9M1Btlr/Irf9+
Genetic
Background		 C57BL/6J-Irf9M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf9M1Btlr mutation (0 available); any Irf9 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased circulating interferon-beta level ( J:236674 )
• slight increase in type I interferon production after dsDNA exposure

cellular
increased cell death ( J:236674 )
• increased rate of macrophage necroptosis after treatment with lipolysaccharide

homeostasis/metabolism
increased circulating interferon-beta level ( J:236674 )
• slight increase in type I interferon production after dsDNA exposure




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory