Phenotypes associated with this allele

• Allele Symbol: Itk^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5806309
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itk^m1Btlr/Itk^m1Btlr	C57BL/6J-Itk^m1Btlr	MGI:5807116

Genotype
MGI:5807116

hm1

• Allelic Composition: Itk^m1Btlr/Itk^m1Btlr
• Genetic Background: C57BL/6J-Itk^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236673 )

• central memory CD8 T cells are increased

increased IgE level ( J:236673 )

abnormal CD4-positive, alpha-beta T cell physiology ( J:236673 )

• mice exhibit a reduced frequency of CD4 T cells in the blood

abnormal CD8-positive, alpha-beta T cell physiology ( J:236673 )

• although the frequency of CD8 T cells was normal, within that population naive CD8 T cells are reduced

cellular

abnormal cell proliferation ( J:236673 )

• effector memory CD4 T cell frequency is also elevated

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236673 )

• central memory CD8 T cells are increased

hematopoietic system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236673 )

• central memory CD8 T cells are increased

increased IgE level ( J:236673 )

abnormal CD4-positive, alpha-beta T cell physiology ( J:236673 )

• mice exhibit a reduced frequency of CD4 T cells in the blood

abnormal CD8-positive, alpha-beta T cell physiology ( J:236673 )

• although the frequency of CD8 T cells was normal, within that population naive CD8 T cells are reduced