All Phenotypes Ppp3cb<m2Btlr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp3cb^m2Btlr/Ppp3cb^m2Btlr	C57BL/6J-Ppp3cb^m2Btlr	MGI:5807111
ht2	Ppp3cb^m2Btlr/Ppp3cb⁺	C57BL/6J-Ppp3cb^m2Btlr	MGI:5807112

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, an increased frequency of effector memory CD8+ T cells and a reduced frequency of nave CD8+ T cells, all in the peripheral blood

abnormal NK cell physiology ( J:236671 )

• some mice exhibit increased expression of CD44 on T cells and on CD8+ T cells as well as an increased frequency of NK cells

abnormal CD4-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

decreased response to antigen ( J:236671 )

• T-dependent antibody response to ovalbumin administered with aluminum hydroxide is also diminished

cellular

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, an increased frequency of effector memory CD8+ T cells and a reduced frequency of nave CD8+ T cells, all in the peripheral blood

hematopoietic system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, an increased frequency of effector memory CD8+ T cells and a reduced frequency of nave CD8+ T cells, all in the peripheral blood

abnormal NK cell physiology ( J:236671 )

• some mice exhibit increased expression of CD44 on T cells and on CD8+ T cells as well as an increased frequency of NK cells

abnormal CD4-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

Allelic Composition	Ppp3cb^m2Btlr/Ppp3cb⁺
Genetic Background	C57BL/6J-Ppp3cb^m2Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cb^m2Btlr mutation (0 available); any Ppp3cb mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, and an increased frequency of effector memory CD8+ T cells, all in the peripheral blood

abnormal CD4-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

cellular

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, and an increased frequency of effector memory CD8+ T cells, all in the peripheral blood

hematopoietic system

increased CD8-positive, alpha-beta memory T cell proliferation ( J:236671 )

• an increased frequency of central memory CD8+ T cells, and an increased frequency of effector memory CD8+ T cells, all in the peripheral blood

abnormal CD4-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

abnormal CD8-positive, alpha-beta T cell physiology ( J:236671 )

• mice show an increase in the B:T cell ratio due to a reduced frequency of T cells including CD4+ T cells and CD8+ T cells

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