Phenotypes associated with this allele

• Allele Symbol: Kbtbd2^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5806297
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kbtbd2^m1Btlr/Kbtbd2^m1Btlr	C57BL/6J-Kbtbd2^m1Btlr	MGI:5806513

Genotype
MGI:5806513

hm1

• Allelic Composition: Kbtbd2^m1Btlr/Kbtbd2^m1Btlr
• Genetic Background: C57BL/6J-Kbtbd2^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

female infertility ( J:236520 )

♀ • female mice become pregnant but fail to deliver pups

male infertility ( J:236520 )

♂

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:236520 )

N • mice exhibit normal serum levels of IGF1

increased fasting circulating glucose level ( J:236520 )

• between 4 and 8 weeks of age

• however, transplantation of wild-type white adipose tissue exhibit rescue of phenotype

increased circulating insulin level ( J:236520 )

• in fasting mice between 4 and 8 weeks of age

• however, transplantation of wild-type white adipose tissue exhibit rescue of phenotype

decreased circulating leptin level ( J:236520 )

increased circulating alanine transaminase level ( J:236520 )

increased circulating aspartate transaminase level ( J:236520 )

insulin resistance ( J:236520 )

• at 8 weeks

decreased adiponectin level ( J:236520 )

• in the serum

increased liver triglyceride level ( J:236520 )

adipose tissue

decreased epididymal fat pad weight ( J:236520 )

decreased inguinal fat pad weight ( J:236520 )

abnormal white adipose tissue physiology ( J:236520 )

• liver and inguinal white adipose tissue fails to respond to insulin at 4 weeks

growth/size/body

increased lean body mass ( J:236520 )

• mice are lean throughout life compared with wild-type mice

decreased body size ( J:236520 )

• within the first few days of birth and through postnatal life

decreased body weight ( J:236520 )

• within the first few days of birth and through postnatal life

postnatal growth retardation ( J:236520 )

• however, transplantation of white adipose tissue partially rescued growth retardation

enlarged liver ( J:236520 )

increased liver weight ( J:236520 )

• however, transplantation of wild-type white adipose tissue exhibit rescue of phenotype

liver/biliary system

enlarged liver ( J:236520 )

increased liver weight ( J:236520 )

• however, transplantation of wild-type white adipose tissue exhibit rescue of phenotype

increased liver triglyceride level ( J:236520 )

hepatic steatosis ( J:236520 )

• however, transplantation of wild-type white adipose tissue exhibit rescue of phenotype

pale liver ( J:236520 )