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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Septin8tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5806071
Summary 2 genotypes


Genotype
MGI:5902374
cn1
Allelic
Composition		 Cnptm1(cre)Kan/Cnp+
Septin8tm1c(EUCOMM)Wtsi/Septin8tm1c(EUCOMM)Wtsi
Genetic
Background		 B6N.Cg-Septin8tm1c(EUCOMM)Wtsi Cnptm1(cre)Kan
Cell Lines EPD0060_3_G04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation (0 available); any Cnp mutation (26 available)
Septin8tm1c(EUCOMM)Wtsi mutation (0 available); any Septin8 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:236408 )
N
• mice exhibit normal developmental myelination
tomacula ( J:236408 )
• in adult mice but not at P15




Genotype
MGI:5902377
cn2
Allelic
Composition		 Septin8tm1c(EUCOMM)Wtsi/Septin8tm1c(EUCOMM)Wtsi
Tg(Plp1-cre/ERT2)1Ueli/0
Genetic
Background		 B6N.Cg-Septin8tm1c(EUCOMM)Wtsi Tg(Plp1-cre/ERT2)1Ueli
Cell Lines EPD0060_3_G04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin8tm1c(EUCOMM)Wtsi mutation (0 available); any Septin8 mutation (31 available)
Tg(Plp1-cre/ERT2)1Ueli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
tomacula ( J:236408 )
• in tamoxifen-treated mice
demyelination ( J:236408 )
• tamoxifen-treated mice exhibit reduction in the spetin scaffold in mature myelin compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory