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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnm1tm2.2Frk
targeted mutation 2.2, Wayne N Frankel
MGI:5800541
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnm1tm2.2Frk/Dnm1tm2.2Frk B6.129(Cg)-Dnm1tm2.2Frk MGI:5800568
ht2
 		Dnm1Ftfl/Dnm1tm2.2Frk involves: 129 * C57BL/6J * FVB MGI:5800569


Genotype
MGI:5800568
hm1
Allelic
Composition		 Dnm1tm2.2Frk/Dnm1tm2.2Frk
Genetic
Background		 B6.129(Cg)-Dnm1tm2.2Frk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm2.2Frk mutation (0 available); any Dnm1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:235711 )
N
• mice do not display spontaneous seizures and exhibit a normal electroconvulsive threshold




Genotype
MGI:5800569
ht2
Allelic
Composition		 Dnm1Ftfl/Dnm1tm2.2Frk
Genetic
Background		 involves: 129 * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (2 available); any Dnm1 mutation (40 available)
Dnm1tm2.2Frk mutation (0 available); any Dnm1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
seizures ( J:235711 )
• non-maximal, non-lethal seizures without interictal events similar to Dnm1Ftfl heterozygotes

behavior/neurological
seizures ( J:235711 )
• non-maximal, non-lethal seizures without interictal events similar to Dnm1Ftfl heterozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory